| Rank | Player | Hometown | Hits |
| 1. | Appling, Luke | High Point | 2749 |
| 2. | Grace, Mark | Winston-Salem | 2445 |
| 3. | Slaughter, Enos | Roxboro | 2383 |
| 4. | Durham, Ray | Charlotte | 2054 |
| 5. | Phillips, Brandon | Raleigh | 2029 |
| 6. | Zimmerman, Ryan | Washington | 1784 |
| 7. | Ferrell, Rick | Durham | 1692 |
| 8. | Goodman, Billy | Concord | 1691 |
| 9. | Lockman, Whitey | Lowell | 1658 |
| 10. | Lewis, Buddy | Gaston Co. | 1563 |
| 11. | Roberts, Brian | Durham | 1527 |
| 12. | Temple, Johnny | Lexington | 1484 |
| 13. | Nixon, Otis | Evergreen | 1379 |
| 14. | Helms, Tommy | Charkotte | 1342 |
| 15. | Burgess, Smoky | Caroleen | 1318 |
| 16. | Seager, Kyle** | Charlotte | 1267 |
| 17. | Hamilton, Josh | Raleigh | 1134 |
| 18. | Wright, Taffy | Tabor City | 1115 |
| 19. | Jones, Charley | Alamance. Co. | 1114 |
| 20. | Hart, Jimmy Ray | Hookerton | 1052 |
| *Based on 1,000 minimum at bats. ** Active player. Stats through 2020 season. |
Biographical Encyclopedia of North Carolinians Who Played Major-League Baseball