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| Rank | Player | SO |
| 1. | Perry, Gaylord | 3534 |
| 2. | Millwood, Kevin | 2083 |
| 3. | Hunter, Catfish | 2012 |
| 4. | Bumgarner, Madison* | 1824 |
| 5. | Wilhelm, Hoyt | 1610 |
| 6. | Perry, Jim | 1576 |
| 7. | Archer, Chris* | 1349 |
| 8. | Cardwell, Don | 1211 |
| 9. | Cloninger, Tony | 1129 |
| 10. | Bibby, Jim | 1079 |
| 11. | Allen, Johnny | 1070 |
| 12. | Meadows, Lee | 1063 |
| 13. | Hitchcock, Sterling | 997 |
| 14. | Ferrell, Wes | 985 |
| 15. | Benton, Rube | 950 |
| 16. | Caldwell, Mike | 939 |
| 17. | Vogelsong, Ryan | 900 |
| 18. | Moehler, Brian | 859 |
| 19. | Baldwin, James | 844 |
| 20. | Lanier, Max | 821 |
| *Active player | | |
