| Rank | Player | .ERA |
| 1. | Shore, Ernie | 2.47 |
| 2. | Wilhelm, Hoyt | 2.52 |
| 3. | Anderson, Fred | 2.86 |
| 4. | Lanier, Max | 3.01 |
| 5. | Benton, Rube | 3.09 |
| 6. | Perry, Gaylord | 3.11 |
| Suggs, George | 3.11 | |
| 8. | Bumgarner, Madison** | 3.20 |
| 9. | Hunter, Catfish | 3.26 |
| 10. | Hall, Tom | 3.27 |
| 11. | Meadows, Lee | 3.37 |
| 12. | Melton, Cliff | 3.42 |
| 13. | Perry, Jim | 3.45 |
| Wood, Alex** | 3.45 | |
| 15. | Abernathy, Ted | 3.46 |
| Andrews, Nate | 3.46 | |
| 17. | Stewart, Sammy | 3.59 |
| 18. | Melton, Rube | 3.62 |
| 19. | Bradley, Tom | 3.72 |
| 20. | Zachary, Tom | 3.73 |
| *Minimum 500 innings pitched | ||
| **Active player |